If you read Tom Spurgeon’s interview with Kevin Cannon you’ll find roughly 317 bits of wisdom. I’ll quote only one, from this not-for-the-squeamish bit about sound effects:
In Far Arden, David’s “THROW UP A LITTLE IN MOUTH” sound effect really cuts right to the core of what he’s feeling and doing, and it only took one panel to accomplish. If I used a normal sound effect like “HRMPH” I suppose some people might deduce that David had thrown up a little in his mouth. But how do we know he hasn’t thrown up a lot in his mouth? Or what if he has merely belched, without any throw-up at all? One solution would be for the character to have the “HRMPH” sound effect, and then to tell another character, “I’ve just thrown up a little in my mouth.” But given the fact that he’s got to spit out the throw-up first before he can attempt to say anything, we’re looking at three, four panels just for that one gag. That’s just wasteful.